Applied Mathematics and Mechanics (English Edition)
题名：Modeling biomembranes and red blood cells by coarse-grained particle methods
作者：H. LI1, H. Y. CHANG1, J. YANG2, L. LU1, Y. H. TANG1, G. LYKOTRAFITIS3
单位：1. Division of Applied Mathematics, Brown University, Providence, Rhode Island 02912, U. S. A;
2. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, U. S. A;
3. Department of Mechanical Engineering, University of Connecticut, Storrs, Connecticut 06269, U. S. A
摘要： In this work, the previously developed coarse-grained (CG) particle models for biomembranes and red blood cells (RBCs) are reviewed, and the advantages of the CG particle methods over the continuum and atomistic simulations for modeling biological phenomena are discussed. CG particle models can largely increase the length scale and time scale of atomistic simulations by eliminating the fast degrees of freedom while preserving the mesoscopic structures and properties of the simulated system. Moreover, CG particle models can be used to capture the microstructural alternations in diseased RBCs and simulate the topological changes of biomembranes and RBCs, which are the major challenges to the typical continuum representations of membranes and RBCs. The power and versatility of CG particle methods are demonstrated through simulating the dynamical processes involving significant topological changes, e.g., lipid self-assembly vesicle fusion and membrane budding.
关键词：coarse-grained molecular dynamics lipid bilayer red blood cell membrane membrane fusion
Cite this article as:
Li, H., Chang, H. Y., Yang, J., Lu, L., Tang, Y. H., and Lykotrafitis, G. Modeling biomembranes
and red blood cells by coarse-grained particle methods. Applied Mathematics and Mechanics
(English Edition), 39(1), 3–20 (2018)
https://doi.org/10.1007/s10483-018-2252-6全文链接：
http://www.amm.shu.edu.cn/EN/abstract/abstract15222.shtml#