《上海大学学报(自然科学版)》2019年25卷3期：357-364
缺血性心肌病与能量代谢研究进展
张剑姝, 徐明
北京大学第三医院 心血管内科, 血管医学研究所, 国家卫生健康委心血管分子生物学与调节肽重点实验室, 分子心血管学教育部重点实验室, 心血管受体研究北京市重点实验室, 北京 100191
摘要 缺血性心肌病伴随着心脏能量代谢的变化，这些变化主要为脂肪酸氧化速率增加和/或葡萄糖氧化途径中糖酵解减少.通过减少脂肪酸氧化或者增加葡萄糖氧化的方式干预能量代谢，能够改善缺血性心肌病的病理变化和心脏功能.随着代谢组学检测技术的发展，针对缺血性心肌病进行早期代谢产物检测手段和机制探索方式更加多样，丰富了目前对缺血性心肌病代谢变化的认知.同时，了解并分析缺血性心肌病的代谢变化能为缺血性心肌病的创新药物研发提供新线索.系统介绍了缺血性心肌病中三大营养物质能量代谢变化，干预不同能量变化在心脏功能障碍中的作用，并探讨通过代谢手段治疗缺血性心脏疾病的可能性.
关键词: 缺血性心肌病 脂肪酸氧化 代谢
Research progress on ischemic heart disease and energy metabolism
ZHANG Jianshu, XU Ming
Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China
Abstract: Ischemia heart disease is often accompanied by cardiac energy metabolism, which is reflected in contractile dysfunction and a decrease in cardiac efficiency. Specific metabolic changes include a relative increase in cardiac fatty acid oxidation rates and an uncoupling of glycolysis from glucose oxidation. Recent evidence suggests that therapeutically regulating cardiac energy metabolism by reducing fatty acid oxidation and/or increasing glucose oxidation can improve cardiac function of the ischemic heart. With the development of metabolomics technology, the detection methods and mechanisms of early metabolites for ischemic cardiomyopathy are further explored. This paper first discusses systematically the change of energy metabolic which contributes to cardiac dysfunction, and then it explores the potential for targeting treatment ischemic heart disease through metabolic pathway.
Key words: ischemia heart disease fatty acid oxidation metabolism
全文链接：http://www.journal.shu.edu.cn/fileup/1007-2861/PDF/20190301.pdf